How much is a bus or train ticket from San Diego, CA to Indianapolis, IN?

All-in bus and train tickets from San Diego, CA to Indianapolis, IN start at $222 one-way on carriers including Amtrak, Greyhound, FlixBus.

How long does the trip from San Diego, CA to Indianapolis, IN take?

The fastest bus or train route from San Diego, CA to Indianapolis, IN takes 41h 42m (07:30 to 01:12).

Where do buses and trains depart in San Diego and arrive in Indianapolis?

Departures in San Diego primarily board at San Diego Santa Fe Depot (SAN) and arrive in Indianapolis at Indianapolis Transit Station.

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San Diego, CA

All

Bus

Train

San Diego, CA → Indianapolis, IN

Routes from San Diego

Indianapolis to San Diego

Terms & Affiliate Disclosure

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Sun, Nov 15 → Tue, Nov 17

Duration: 51h 20m

•

4 transfers

Downtown SD (Seaport)

FlixBus #2017

$18

Book Leg

13:10

Los Angeles Union Station

16:55

Free Wi-Fi

Outlets

Restroom

Transfer time: 1h 5m

Station info

Los Angeles Union Station

Greyhound #US0900

$27

Book Leg

18:00

Las Vegas Bus Terminal

23:45

Free Wi-Fi

Outlets

Restroom

Backup 5G eSIM (Saily)

Transfer time: 0h 50m

Station info

Next day: Mon, Nov 16

Las Vegas Bus Terminal

Greyhound #US1200

$76

Book Leg

00:35

Denver Union Station Bus Concourse

17:40

Free Wi-Fi

Outlets

Restroom

Backup 5G eSIM (Saily)

Transfer time: 1h 50m

Station info

Denver Union Station Bus Concourse

Greyhound #US1200

$80

Book Leg

19:30

St Louis Bus Station

13:15

Free Wi-Fi

Outlets

Restroom

Backup 5G eSIM (Saily)

Next day: Tue, Nov 17

Transfer time: 0h 50m

Station info

St Louis Bus Station

Greyhound #US0421

$21

Book Leg

14:05

Indianapolis Bus Station

19:30

Free Wi-Fi

Outlets

Restroom

Backup 5G eSIM (Saily)

$222

Full Route Total • 5 legs

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Book the entire route in one search or book each carrier leg directly:

Full Route Price & Ticket Breakdown

$222 total

1. San Diego, CA → Los Angeles, CA

FlixBus Official #2017 • 13:10–16:55

$18

Book Leg

2. Los Angeles, CA → Las Vegas, NV

Greyhound Official #US0900 • 18:00–23:45

$27

Book Leg

3. Las Vegas, NV → Denver, CO

Greyhound Official #US1200 • 00:35–17:40

$76

Book Leg

4. Denver, CO → St Louis, MO

Greyhound Official #US1200 • 19:30–13:15

$80

Book Leg

5. St Louis, MO → Indianapolis, IN

Greyhound Official #US0421 • 14:05–19:30

$21

Book Leg