How much is a bus or train ticket from Syracuse, NY to St Louis, MO?

All-in bus and train tickets from Syracuse, NY to St Louis, MO start at $111 one-way on carriers including Greyhound, Amtrak.

How long does the trip from Syracuse, NY to St Louis, MO take?

The fastest bus or train route from Syracuse, NY to St Louis, MO takes 17h 32m (07:30 to 01:02).

Where do buses and trains depart in Syracuse and arrive in St Louis?

Departures in Syracuse primarily board at Syracuse Transit Station and arrive in St Louis at St. Louis Gateway Transportation Center (STL).

Loading route...

Syracuse, NY

All

Bus

Train

Syracuse, NY → St Louis, MO

Routes from Syracuse

St Louis to Syracuse

Terms & Affiliate Disclosure

Privacy

Sun, Nov 15

Duration: 19h 20m

•

4 transfers

Syracuse Bus Station

Greyhound #US0215

$33

Book Leg

04:30

Buffalo

07:30

Free Wi-Fi

Outlets

Restroom

Transfer time: 0h 25m

Station info

Buffalo

Greyhound #US0170

$42

Book Leg

07:55

Cleveland Bus Station (Brook Park)

11:40

Free Wi-Fi

Outlets

Restroom

Transfer time: 0h 40m

Station info

Cleveland Bus Station (Brook Park)

Greyhound #US0420

$19

Book Leg

12:20

Toledo Bus Stop

14:05

Free Wi-Fi

Outlets

Restroom

Transfer time: 1h

Station info

Toledo Bus Stop

Greyhound #US0112

$48

Book Leg

15:05

Indianapolis Bus Station

19:25

Free Wi-Fi

Outlets

Restroom

Backup 5G eSIM (Saily)

Transfer time: 0h 30m

Station info

Indianapolis Bus Station

Greyhound #US0421

$44

Book Leg

19:55

St Louis Bus Station

22:50

Free Wi-Fi

Outlets

Restroom

$186

Full Route Total • 5 legs

Book Full Route

Book the entire route in one search or book each carrier leg directly:

Full Route Price & Ticket Breakdown

$186 total

1. Syracuse, NY → Buffalo, NY

Greyhound Official #US0215 • 04:30–07:30

$33

Book Leg

2. Buffalo, NY → Cleveland, OH

Greyhound Official #US0170 • 07:55–11:40

$42

Book Leg

3. Cleveland, OH → Toledo, OH

Greyhound Official #US0420 • 12:20–14:05

$19

Book Leg

4. Toledo, OH → Indianapolis, IN

Greyhound Official #US0112 • 15:05–19:25

$48

Book Leg

5. Indianapolis, IN → St Louis, MO

Greyhound Official #US0421 • 19:55–22:50

$44

Book Leg